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The newest hyaluronic acid filler featuring Cold-X Technology. This innovative manufacturing process preserves the natural structure of hyaluronic acid for smooth results that integrate seamlessly with your skin.
Evolysse represents the latest advancement in hyaluronic acid dermal fillers. Developed by Evolus—the same company behind Jeuveau neurotoxin—Evolysse uses proprietary Cold-X Technology that preserves the natural, long-chain structure of hyaluronic acid during manufacturing. This results in a filler that integrates more naturally with your skin tissue.
The Evolysse line currently includes two formulations: Evolysse Form for deeper folds and volume restoration, and Evolysse Smooth for fine lines and superficial wrinkles. Both are approved for correction of moderate to severe nasolabial folds in adults 22 and older. Clinical studies demonstrated Evolysse's superiority over Restylane-L in head-to-head trials.
What makes Evolysse unique is its Cold-X Technology manufacturing process. Traditional HA fillers use heat and chemical crosslinking that can alter the natural structure of hyaluronic acid. Evolysse's cold processing method maintains the natural HA configuration, allowing for smoother integration with facial tissue.
Proprietary cold processing method preserves the natural long-chain structure of hyaluronic acid for optimal tissue integration.
Preserved HA structure integrates smoothly with facial tissue for results that look and feel natural.
See smoothing and volume restoration immediately after treatment with results that continue to improve as product settles.
Rigorously tested in clinical trials for moderate to severe nasolabial folds in adults 22 and older.
Contains lidocaine for pain relief during injection, ensuring a comfortable treatment experience with minimal discomfort.
Adults 22 years of age and older
Moderate to severe nasolabial folds (smile lines)
Seeking natural-looking filler results
Interest in the latest filler technology
Good overall health without active skin infections
Realistic expectations about injectable treatment outcomes
Evolysse is the newest hyaluronic acid dermal filler available. What sets Evolysse apart is its proprietary Cold-X Technology manufacturing process. Unlike traditional fillers that use heat and chemical crosslinking (which can alter HA structure), Evolysse uses a cold processing method that preserves the natural long-chain structure of hyaluronic acid. This results in smoother tissue integration.
Cold-X Technology is Evolysse's proprietary manufacturing process developed by Evolus. Traditional HA fillers are processed using heat and chemical crosslinking agents, which can break down and alter the natural structure of hyaluronic acid molecules. Cold-X Technology uses low-temperature processing that preserves the natural, longer-chain HA structure found in your own skin. This preserved structure allows Evolysse to integrate more naturally with facial tissue.
Yes, Evolysse is a hyaluronic acid filler, so it can be dissolved with hyaluronidase enzyme if needed. This is the same reversal agent used for other HA fillers like Juvéderm and Restylane. However, Evolysse's natural integration typically produces results that patients are happy with, making reversal rarely necessary.
Evolysse is manufactured by Evolus, the same company that produces Jeuveau neurotoxin. Evolus has established a reputation for innovation in aesthetic medicine, and Evolysse represents their entry into the dermal filler market. The company has additional Evolysse products in development, including Evolysse Sculpt for volumization and Evolysse Lips for lip enhancement.
Evolysse is currently approved for correction of moderate to severe nasolabial folds (smile lines) in adults 22 years of age and older. The line includes two formulations: Evolysse Form for deeper folds and Evolysse Smooth for finer lines. During consultation, your provider will assess whether Evolysse is the right choice for your specific concerns.
VYCROSS (Juvederm) and HYLACROSS (Restylane) use heat and chemical crosslinking to modify HA molecules, creating their distinctive gel properties. Cold-X Technology uses low-temperature processing that preserves the natural long-chain HA structure without heat degradation. Think of it as the difference between cold-pressed juice (preserves nutrients) vs. pasteurized juice (heat-processed). Both approaches create effective fillers, but Cold-X maintains HA in its most natural state.
Evolysse currently includes Evolysse Form and Evolysse Smooth for nasolabial folds. Evolus has announced Evolysse Lips is in development and is expected to be available around 2027. In the meantime, your provider offers excellent lip filler options including Restylane Kysse (our top recommendation for lips) and Juvederm Volbella.